Diabetes mellitus is a metabolic disorder in endocrine system. In order to management of diabetic complications different part of Azadirachta indica alcoholic extraction was used in Alloxan induced diabetic mice. It was observed that treatment of the diabetic mice with ethanolic extract of leaves and seeds of A.indica at a dose of 500 mg/kg body weight and 200 mg/kg body weight for 28 days. It was observed that blood glucose level total cholesterol, triacylglycerol, ALP, SGPT and SGOT were gradually decreased after treatment with leaves and seed extract (significant fall (P<0.05). The data suggests that seeds of A.indica could be of more useful in diabetes mellitus in controlling the blood sugar or may also be helpful in preventing or delaying the onset of the disease.