Fluoride is an environmental pollutant, which induce various anomalies such as skeletal fluorosis, osteoporosis, dental fluorosis and arthritic pains. In an invivo genotoxicity investigation of the action of fluoride one bone marrow cells of mice, take laboratory in bred albino swiss mice (Mus musculus) of average body weight 25-30g were fed orally 1 ppm and 2 ppm for 14 days. Among randomly 300 metaphase plates screened, both individual and gross type chromosome abnormalities were observed. Among individual type or structural type (10.66 % ) and gross type (3.00%) respectively at 1 ppm and at 2 ppm (21.66%) structural and (5.33%) gross type in compare to control (2.66%) structural and (1.33%) gross type obnormalities respectively. The increase in frequency of chromosomal anomalies was mainly due to significant increase in both gross and structural or individual type in compare to control. Thus the effect was does dependent.