Profenofos pesticides commonly used in agriculture have profound effect on mammalian system.
As a organophosphate pesticide profenofos is vigorously used in different agricultural crops to get rid of multiple pests. Field Rats depend upon cultivated seeds and fruits and in turn heavily infested with profenofos. It has deleterious effect on endocrine and can cause severe damage to
certain tissues and biomolecules. Curcuma longa is a well known aurvedic and household medicine and have strong remedial property for thyroid and diabetes through the well known active compound curcumin. Swiss albino mice were exposed with profenofos (50mg/kg b.w) daily for 30 days orally after that curcumin treatment (120mg/kg b.w) upto 30 days and it was noticed that due to profenofos TSH 0.65μIU/ml, T3 64ng/dl and T4 3.6μg/dl and Glucose 51.23 mg/dl. After the treatment with curcumin these parameters get changed to TSH 0.2 μIU/ml, T3146 ng/dl,
T45.7μg/dl and Glucose103.9 mg/dl. On the basis of this observation it was observed that hypogalaceamia and hypothyroid is recovered by the treatment of curcumin.