Achyranthes aspera (Amaranthaceae) is an important medicinal herb found as weed throughout India. It
has been used in almost all the traditional system of medicine, Ayurveda, Unani, and Sidha since ancient
time. The present study discuss about the antibacterial activity of Achyranthes aspera against Escerichia
coli, Staphylococcus aureus and Pseudomonas fluorescence and minimum inhibitory concentration (MIC)
was also determined. It was found that the extracts shown excellent inhibitory activity against Bacillus
subtilis. MIC obtained from bacterial strains for methanol and aqueous extract, leaf extract of Azadirachta
indica was mixed in different concentration and again the MIC of A. aspera was noted and found that
with 50μl/ml. dilution of A. indica in 200μl/ml. of A.aspera inhibitory activity takes place which increases
with increase in concentration. The present study is the first study on all parts of Achyranthes aspera
which combines these different parameters in it including the mixing of plant extracts with A. indica leaf
extract.